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PhD student positions – Imaging analysis of dynamic events in HIV-1 host-interaction



The Department of Infectious Diseases, Virology at the University Hospital Heidelberg, Germany offers positions for PhD studentsworking on Lipid-protein interactions in HIV-1 assembly, onHigh resolution analysis of early HIV-1 replication or on Dynamics of HIV-1 post-entry events in the groups of Prof. Dr. Hans-Georg Kräusslich and Prof. Dr. Barbara Müller.


The interaction of human immunodeficiency virus with its host cell involves numerous highly dynamic steps that are difficult or impossible to investigate by classical approaches. Therefore, our groups apply advanced imaging techniques to study dynamic events and structural details in HIV-1 assembly at the plasma membrane and in early post-entry stages of HIV-1 replication. In one project, we specifically focus on HIV-1 lipid-protein interactions at the plasma membrane, which are essential to form the specific lipid envelope of infectious HIV-1 particles and to stably recruit virion components to the assembly site. Other projects address post-entry stages of HIV-1 replicationwith a focus on either structural aspects applying super-resolution and correlative light- and electron microscopy or on dynamic aspects focusing on live cell imaging and novel labeling technologies. We investigate transport and uncoating of the viral capsid, reverse transcription of the viral genome and nuclear translocation of the resulting complex in different target cells. These processes are complex and require tight regulation in space and time; post-entry events are further influenced by numerous host cell restriction and dependency factors. There are many open questions (including surprisingly basic ones) for example “How are lipids and glycoproteins recruited to the HIV-1 assembly site?”, or “How are viral genomes shielded from DNA sensors and delivered to the nucleus?”.


We offer interesting, interdisciplinary research topics with biomedical relevance in an interactive scientific environment, including collaborations with national and international partners, at an internationally competitive level. The labs are located in the newly opened Center for Integrative Infectious Disease Research on the Heidelberg campus, which also houses a state-of-the-art imaging platform. Successful candidates have the possibility to apply for the HBIGS International Graduate School to fully benefit from the excellent scientific training of this program.


Applicants should have a Master degree (biology, biochemistry, possibly biophysics or molecular medicine) and be interested in addressing basic virological questions using different methods with a strong focus on imaging techniques. A good background in standard molecular biological methods is expected. Ideal candidates have a particular interest and some experience in fluorescence microscopy and image analysis, together with a background in cell biology, biochemistry or biophysics.


We are looking forward to meet students motivated by intrinsic scientific curiosity, who enjoy working independently, but also love to interact, discuss and collaborate with scientists from different disciplines and nations.



Positions are open immediately; deadline for applications is March 18th, 2018.


Please address your applications including CV, summary of academic records, and letters of recommendation or contact details of potential referees (as a single pdf file) to:



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