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The Department of Infectious Diseases, Virology at the University Hospital Heidelberg, Germany offers positions for PhD students working on Lipid-protein interactions in HIV-1 assembly, on High resolution analysis of early HIV-1 replication or on Dynamics of HIV-1 post-entry events in the groups of Prof. Dr. Hans-Georg Kräusslich and Prof. Dr. Barbara Müller.

 

The interaction of human immunodeficiency virus with its host cell involves numerous highly dynamic steps that are difficult or impossible to investigate by classical approaches. Therefore, our groups apply advanced imaging techniques to study dynamic events and structural details in HIV-1 assembly at the plasma membrane and in early post-entry stages of HIV-1 replication, asking questions like “How are lipids and glycoproteins recruited to the HIV-1 assembly site?”, or “How are viral genomes shielded from DNA sensors and delivered to the nucleus?”. In one project, we specifically focus on HIV-1 lipid-protein interactions at the plasma membrane. Other projects address post-entry stages of HIV-1 replication with a focus on either structural aspects applying super-resolution and correlative light- and electron microscopy, or on dynamic aspects focusing on live cell imaging and novel labeling technologies.

 

We offer interesting, interdisciplinary research topics with biomedical relevance in an interactive scientific environment, including collaborations with national and international partners, at an internationally competitive level. The labs are located in the newly opened Center for Integrative Infectious Disease Research, which also houses a state-of-the-art imaging platform.

 

Applicants should have a Master degree (biology, biochemistry, possibly biophysics or molecular medicine). They should be interested in addressing basic virological questions using different methods, with a strong focus on imaging techniques. A good background in standard molecular biological methods is expected. A particular interest and some experience in fluorescence microscopy and image analysis is a strong asset.

 

We are looking forward to meet curious students who are enthusiastic about science. They should enjoy working independently, but also love to interact, discuss and collaborate with scientists from different disciplines and nations.

 

Positions are open immediately. Deadline for application is May 22, 2018.

 

Please address your applications including CV, summary of academic records, and letters of recommendation or contact details of potential referees (as a single pdf file) to: Barbara_Mueller@med.uni-heidelberg.de

 

 

Mücksch et al., (2017). Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. Elife. 6. pii: e25287. doi: 10.7554/eLife.25287.

Sakin et al. (2017). A versatile tool for live-cell imaging and super-resolution nanoscopy studies of HIV-1 Env distribution and mobility. Cell Chem Biol. 24:635-645.e5

Mattei et al. (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science. 2016 Dec 16;354(6318):1434-1437.

Hanne et al. (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-22.

Peng et al. (2014) Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. eLife 2014 10.7554/eLife.04114

Sakin et al. (2016). Labeling of virus components for advanced, quantitative image analyses FEBS Lett 590:1858-1876

Hanne et al. (2016) Super-resolved insights into human immunodeficiency virus biology. FEBS Lett. doi: 10.1002/1873-3468.12186

Kontakt: 
Barbara_Mueller@med.uni-heidelberg.de